Estratetraenol

Overview

Estratetraenol (estra-1,3,5(10),16-tetraen-3-ol) is a putative female pheromone found in female sweat and pregnant woman's urine. It's structurally related to estrogens but has NO estrogenic activity due to the C16=C17 double bond replacing the 17β-hydroxyl group.

The community is divided on its usefulness, with some viewing it as a comfort enhancer and others arguing it signals "pregnancy" and kills sexual attraction.

Pharmacology

What It Is

Estratetraenol (estra-1,3,5(10),16-tetraen-3-ol) is a C18 estratetraene steroid — an estrane skeleton with four double bonds (at C1-C2, C3-C4, C5-C10, and C16-C17), plus a 3-hydroxyl (phenolic OH). Molecular formula C₁₈H₂₂O, MW 254.37. Despite being structurally related to estrogens, it has NO estrogenic activity — the C16=C17 double bond replaces the 17β-hydroxyl group that is essential for estrogen receptor binding.

Biosynthesis

Estratetraenol is found in female sweat and pregnant women's urine, consistent with its characterization as a putative female pheromone. Its biosynthetic pathway is not fully elucidated but it is derived from the estrane/estrogen pathway:

Cholesterol → Pregnenolone → DHEA → Androstenedione → Estrone → Estratetraenol
                                                                  (via 16-dehydration)

Detection & Chemistry

Detected via VNO (close-range, non-volatile). The 16-position double bond is chemically critical:

Replaces the 17β-OH required for estrogen receptor binding → non-estrogenic
Any compound marketed as "estratetraenone" with a 16-double bond is chemically impossible — the C17 ketone position is occupied by the double bond
The aromatic A-ring (phenol) provides some polarity, limiting volatility

Detection Pathway

Estratetraenol is non-volatile (no vapor pressure data available, estimated very low). Detection is likely through:

VNO pumping mechanism: Mucus transport of non-volatile compounds
Direct contact: Close-proximity interactions

This explains why effects are primarily seen in intimate/close settings rather than diffusively.

Related Compounds

Compound	CAS	Difference
Methoxyestratetraenol (MEO-EST)	28336-31-4	Methyl ether - more potent, non-prodrug
Estratetraenol acetate	Unknown	Acetate ester - prodrug form
8,9-Dehydroestrone	474-87-3	DIFFERENT - horse estrogen, IS estrogenic

Important Warnings

Mislabeling Issues

Many vendors sell "estratetraenone" which is chemically problematic:

The 16-position double bond precludes a 17-ketone
May actually be 8,9-dehydroestrone (horse estrogen, IS estrogenic)
Or mislabeled methoxyestratetraenol
Always verify CAS numbers

Not for HRT

Despite the name similarity to estrogens, estratetraenol has zero estrogenic activity and is not suitable for hormone replacement.

Character

Moderate evidence · 29 posts

the vulnerable sweetheart

Wearing this wraps you in a protective, comforting aura that makes others treat you with gentle, non-sexual care and nurturing concern.

the love scent
vulnerable and sensitive
nurturing/hand holding
paternalistic
feel good thing
pregnant womans scent
disinhibition

Effect profile PheromoneXS GOALS

calmingprime7Content
engaging4Excited
status0Optimistic
social2nd6Friendly
playful3Happy
flirting2Courageous
intimate5Loving
sexual1Pleasurable

Where it sits

BondingDominance
IntrospectiveOutgoing
ApproachableIntimidating

Androgenic: feminine
Self-effect: 5/10
Timing: day/night
Duration: 2 to 3 hours

It is produced naturally by child-bearing women and is read as a highly feminizing signal that can confuse male wearers' sexual presentation.

Shadow.Can trigger hostile reactions if not in the right blend, or cause partners to completely ignore the wearer, stripping away sexual attraction in favor of a non-sexual, protective 'pregnant woman' caretaking vibe.

Dose.Can be touchy; too much can cause separation/bitter taste in DIY lip gloss, or trigger hostility/complete ignoring from partners if overdosed, though some report success upping the dose for intimate settings.

Works on.Husbands/partners in intimate, relaxed settings, or in predominantly male environments for extra compliance or protection.

Backfires on.Men seeking direct sexual/alpha attraction from women (who may view them as non-sexual or 'pregnant'), or partners who are highly sensitive to it and react with hostility or total avoidance.

Stacks with.copulins, Androstadienone, Corporativo, TAH

In their words

This product does give women the feeling of caring but not sexual caring. It's more like watching over the pregnant lady and making sure she is OK.

PheroTruth, post 25978

I usually don’t get self effects from Pheromones, but I want to say that I felt more vulnerable and sensitive sometimes when I wore EST.

PheroTruth, post 189031

Haha TT gets has a hostile reaction to est. if it's not in the right blend !

PheroTruth, post 10173

Synthesised from archived PheroTruth threads. Every quote is verified verbatim against the post it cites. The archive holds roughly 29% of the forum's posts and over-represents opening posts, so read thin profiles with that in mind.

Community Effect Profile

Multi-dimensional effect ratings from community reports. The shaded area shows variance (standard deviation).

Moderate confidence — 7 reports

Effects

Effects on Others (Targets)

Mood boosting and "feel good" energy: People exposed to EST instantly get a brighter disposition and feel uplifted, energized, and more social in the wearer's presence.
Nurturing/protective response from men: When worn by women, men feel they need to protect the wearer, perceiving them as vulnerable. Men act more chivalrous and affectionate. Note: some men find the vulnerability signal irritating rather than attractive.
Comfort and warmth signals: Non-sexual warmth and caring perception.
Femininity amplification: Can make women feel adored, more "girly," and more ditsy. Not necessarily negative but can reduce status perception in professional environments at high doses.
Buffer against aggression: Used in extremely small doses in male pheromone formulas to offset aggressive alpha molecules.

Effects When Worn by Men

Excellent mood booster and stress reliever: In small doses, men find EST to be a genuine "feel good" molecule.
Warning -- weakness signals: In early testing by HoP, men wearing EST found that others tried to "protect" them from normal banter, perceiving them as unable to handle it. For men, giving off weak signals is not attractive.
Vulnerability perception: Men may be perceived as physically weaker and more womanly.

Controversy: The Pregnancy Signal Theory

Some community members (notably Paradox on the forums) argue that EST signals pregnancy and therefore reduces sexual attraction. The theory:

Pregnant women produce EST
Male response to pregnancy = protection, not sexual interest
Therefore EST "friendzones"

Counter-argument: Others find it useful as a comfort buffer that creates trust without the romantic intensity of androstadienone. The HoP perspective is that EST is a legitimate female pheromone with real nurturing and protective effects, not just a pregnancy signal.

Dosage Guidelines

Level	Amount
Light	3-15 mcg
Moderate	15-40 mcg
Strong	40-80 mcg

Notes:

Primarily used at trace amounts (3 mcg range) as an aggression buffer in male blends
Higher doses (15+ mcg) are more typical for women's use
Best used in combination, not solo
Higher doses may emphasize "comfort zone" effect

Application Tips

Best Application Points

Neck / behind ears
Wrists
Chest (under clothing)
Forearms

Timing

Apply 15-30 min before social interaction
Reapply every 4-6 hours if needed
Morning application works for all-day wear

Avoid

Applying immediately before close contact
Using strong cover scents that mask effect
Applying to clothing (oils can stain)

Have experience with Estratetraenol? Share your dosage notes in the Community tab.

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Research Overview

Scientific studies and research related to Estratetraenol. Search PubMed for CAS 1150-90-9 for more studies.

🔬 Search PubMed 📚 Google Scholar 🧪 PubChem

Key Findings

Summary of important research findings related to Estratetraenol.

Research Summary Coming Soon

We're compiling peer-reviewed research on Estratetraenol. In the meantime, use the search links above to find published studies.

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Research Context

Detection Studies

Research on how humans detect this compound, including olfactory receptor studies and perception genetics (e.g., OR7D4 variants).

Learn about detection →

Behavioral Studies

Studies examining behavioral and psychological effects of exposure, including mood, attraction, and social behavior changes.

Browse studies →

Receptor Biology

Research on receptor binding, including GABA-A modulation, steroid receptor interactions, and neural signaling.

Learn about receptors →

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Products Containing Estratetraenol

Commercial pheromone products that include Estratetraenol in their formula.

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Buying Guide

Concentration Matters

Products vary widely in Estratetraenol concentration. Higher isn't always better — check dosage guidelines on the Effects tab.

Formula Synergy

Estratetraenol is often combined with other molecules. The overall formula balance affects the final effect more than any single ingredient.

Vendor Reputation

Stick to established vendors with verifiable lab testing. Check vendor pages for community reputation and reviews.

DIY Option

For experienced users, raw Estratetraenol is available from some vendors.

Raw Materials

Raw pheromone molecules can be purchased and diluted in carrier oils (DPG, alcohol, etc.) for custom formulations.

Note: DIY requires precise measurement equipment and knowledge of safe concentrations. Start with pre-made products.

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