Methoxyestratetraenol

Overview

Methoxyestratetraenol (MEO-NOL) is the methyl ether derivative of estratetraenol — the -OH (alcohol) variant, not the ketone. This is a critical distinction: MEO-NOL and methoxyestratetraenone (MEO-EST-one) are different compounds with different safety profiles.

Alpha Dream (Chris) was the primary advocate for the -nol variant, working to purify it to 99% in 2012 while simultaneously refusing to stock the -one variant on safety grounds:

"That's why I don't stock or use estratetraenone or meo-estratetraenone: I know that it's not good for people to use." — Alpha Dream, PheroTruth 2012

Note: Most community reports labeled "MEO-EST" don't specify which variant. As of late 2011, user dbot noted that nobody had tested the -nol version — all early reports were about the -one. This page covers what is specifically known about the -nol. For the ketone variants and their identity controversy, see Methoxyestratetraenone.

Pharmacology

What It Is

Methoxyestratetraenol (C₁₉H₂₄O, MW 268.39, CAS 28336-31-4) is the methyl ether of estratetraenol — the 3-hydroxyl group is capped with a methyl group (-OCH₃ instead of -OH). This is a stable modification: the methyl ether bond is NOT cleaved by the body, so this is NOT a prodrug — it acts as its own distinct compound.

Key Properties

• Non-estrogenic — the C16=C17 double bond + methoxy group eliminate estrogen receptor binding. This is why Alpha Dream considered it safe while rejecting the ketone variant.
• Slightly more volatile than EST — blocking the -OH removes hydrogen bonding capacity, lowering intermolecular attraction
• Detected via VNO at close range

Known Products

The -nol is much rarer than the -one in commercial products:

• Impi Red Dot (Pago/ApexPheromones) — user Ekscentra confirmed: "Impi for sure contains MeO-NOL. I'd spot that one from a mile away."
• Alpha Dream concentrates (planned 2012) — Chris was purifying MEO-NOL to 99% but it's unclear if it was released as a standalone single molecule
• Pago — at least one tester reported buying MEO-NOL directly from Pago

Most products labeled "MEO-EST" on the market contain the -one variant (likely equilin methyl ether, CAS 6030-83-7), not this compound.

Naming Confusion

The community uses "MEO-EST" for both the -nol and the -one. This has caused decades of confused reports:

When someone says "MEO-EST" without specifying, they are more likely talking about the -one, since that's what most vendors sell. The -nol is rarer and harder to source.

Comparison with Related Compounds