Methoxyestratetraenone

Overview

"Methoxyestratetraenone" is where pheromone chemistry meets an identity crisis. The community often uses "MEO-EST" interchangeably for both the -nol and -one variants, but the ketone version has a much more complicated story.

The core problem: Three different compounds have been sold or discussed under variations of the "MEO-EST" name, and the one available today is almost certainly not the same molecule that Androtics Research originally sold. The glowing community reports (9/10 ratings, "MSG of pheromones") largely come from the Androtics era and may describe a compound that is no longer commercially available.

Alpha Dream (Chris) started a PheroTruth poll in January 2012 asking the community directly:

"Need your opinions. Should methoxyestratetraenone be available on the open market, despite the inherent estrogenic potential of the compound? Is it really good enough to negate the potential side effects?" — Alpha Dream, PheroTruth 2012

He later made his position clear, refusing to stock it:

"That's why I don't stock or use estratetraenone or meo-estratetraenone: I know that it's not good for people to use, and won't accept the ruthless profitability model that is all too common nowadays, regardless of their customer's well being." — Alpha Dream, PheroTruth 2012

Note: For the -nol variant (non-ketone, non-estrogenic, CAS 28336-31-4), which Alpha Dream considered safe and was purifying to 99%, see Methoxyestratetraenol.

The Three Candidates

All three share the estrane (C18) skeleton with a 3-methoxy group and C17 ketone. The only difference is where the 4th double bond sits — but this dramatically changes estrogenic activity.

Effects

Why the 9(11) Variant May Be the "Real" MEO-EST

Two features work together to reduce estrogenic activity in the 9(11) variant:

1. C9=C11 double bond — flattens the B, C, and D rings, distorting the molecule's 3D shape. Poor fit in the estrogen receptor binding pocket (~20% of estradiol)
2. 3-Methoxy group — blocks the phenolic OH at C3, removing ~1.9 kcal/mol of ER binding energy

Combined effect: likely much less than 20% of estradiol's ER binding. This could make it estrogenic enough to "signal" femininity/comfort without meaningfully activating estrogen receptors — the sweet spot for pheromonal use.

If Androtics was telling the truth about "human origin," their MEO-EST was probably this 9(11)-tetraene variant — a molecule with:

• Enough estrane character for pheromone signaling
• Distorted geometry that limits estrogen receptor activation
• The "MSG of pheromones" enhancer effect at low doses

Why the Equilin Version (Currently Sold) Is Different

The C7=C8 double bond in equilin methyl ether does the opposite — it extends conjugation from the A-ring into the B-ring, enhancing planarity and estrogen receptor fit. Combined with only the methoxy reduction, the net result is a more estrogenic molecule.

This may explain:

• Estrogenic side effects (migraines, mood issues) at moderate doses
• The recommendation to spray on clothing only
• The disconnect between Androtics-era reports and current user experiences

Reported Effects (Androtics era, possibly 9(11) variant)

• Social buffer — smooths rough edges, "get out of jail free card"
• Mood boost for wearer
• Called the "MSG of pheromones" — enhances everything around it
• Does NOT friendzone like some report with EST
• "Crush" vibe — similar to True Love (TL) and Nude Alpha (NA)
• Relationship stabilizer — calms emotional volatility in partners

Community member kmacc45 reported at 100 mcg:

"Was having problems with my Girl a couple of weeks ago. Nothing I did would calm the she-devil in her. Pago suggested 100 mcg of Methoxyestratetraenone and I've been able to enjoy better times with her. It's not something I want to use everyday, because of the health scares." — kmacc45, PheroTruth 2012

When asked to distinguish it from androstadienone:

"Methoxyestratetraenone was like instant piece of mind. Dienone increased that loving feeling but never stabilize the relationship." — kmacc45, PheroTruth 2012

Community member Oasis defended its use:

"Methoxyestratetraenone has helped many people in terms of relationships and has its downsides of estrogenic properties in it. Will I stop using it? Hardly, when used in moderation, it shines." — Oasis, PheroTruth 2012

Safety Concerns

The estrogenic risk was always the elephant in the room. Early concerns included:

• SeriousSmile voted against market availability: "Just the idea of it being produced from cancerous cells or horse steroid makes me wary of spraying it on myself."
• Beccah (healthcare background) theorized the compound may be a natural cancer marker: "Methoxyestratetraenone may be produced by cancerous human breast tissue as a chemical indicator to men that this woman isn't a good bet, genetically speaking."
• andromun warned about end-user behavior: "Even though you can lessen the risk by spraying it on your clothes or avoid an excessive amount of sprays... people are people and won't heed the potential risks."
• Allergic reactions reported by some users — one member noted sensitivity from either EST or methoxyestratetraenone

Current Supply Reports (likely equilin ME)

• Some estrogenic side effects at moderate doses
• Migraines reported by some users
• Less consistent reports than Androtics era
• May still buffer at low doses, but narrower effective range

Dosage Guidelines

Warning for current supply: If using equilin methyl ether (CAS 6030-83-7), be aware of higher estrogenic potential. Start low. Consider applying to clothing rather than skin at higher doses — this was the consistent community advice even in the Androtics era.

Carrier: DPG recommended for extended duration. Alcohol-based carriers may increase dermal absorption.

Known Products

• True Pheromones — sold both methoxyestratetraenol and methoxyestratetraenone as standalone single molecules
• Androtics Research — included in several formulas (likely 9(11) variant, no longer available)
• True Love (True Pheromones) — described as having a "crush" vibe, frequently compared to MEO-EST effects. Contains androstadienone as primary molecule with estratetraenol

Most products labeled "MEO-EST" on the market today likely contain equilin methyl ether (CAS 6030-83-7), not the 9(11) variant from the Androtics era.

Combinations

Androtics-Era Stacks

• MEO-EST + Androstenone: Buffers the aggression while the -one provides edge
• MEO-EST + Androstadienone: Both comfort/romance molecules, can stack but watch total estrogenic load
• MEO-EST + Alpha formulas: Insurance against overdosing aggressive molecules

Caution

Unlike the -nol variant which has a wide safe dosing range, stacking the -one with other estrogenic molecules (EST, androstadienone) increases cumulative estrogenic exposure. Monitor for side effects.

Structural Breakdown

All three candidates have the aromatic A-ring (C1=C2, C3=C4, C5=C10 = triene base). The 4th double bond location is what differs:

Equilin ME — C7=C8 extends conjugation through the B-ring, enhancing molecular planarity. This IMPROVES estrogen receptor fit.

9(11) variant — C9=C11 at the B/C ring junction FLATTENS the alicyclic rings (B, C, D), distorting the 3D shape. This REDUCES estrogen receptor fit.

Methoxy-estrone — No 4th double bond. Normal estrone shape with the C3-OH methylated. Moderate ER binding.

The Supply Problem

The 9(11)-tetraene variant does not appear to have:

• A registered CAS number
• A commercial supplier
• Any current production

It exists only in a 1977 RSC synthesis paper. If this was indeed what Androtics sold, their source is unknown and may no longer exist.

What's available today under "MEO-EST" names is almost certainly equilin methyl ether (CAS 6030-83-7) — a compound that's structurally closer to an actual estrogen.

Naming Confusion

When someone says "MEO-EST" without specifying, they are more likely talking about the -one, since that's what most vendors sold. However, the -one that was sold in the Androtics era is likely not the same -one sold today.

Sources

• 1977 RSC synthesis of 9(11)-tetraene variant
• ER binding of 9(11)-dehydro steroids
• Steroid structure-activity relationships
• PheroTruth forum: "Methoxyestratetraenone?" thread (Research Forum, Jan 2012)
• PheroTruth forum: Alpha Dream safety refusal (thread-6071, 2012)

Community Consensus

Rating: 6/10 (weighted between Androtics-era glory and current supply reality)

The community consensus on "MEO-EST" is built on years of Androtics-era reports that may not apply to current supply. The molecule sold today is likely equilin methyl ether — more estrogenic, with a narrower effective range and more side effects.

The Androtics-era compound earned descriptions like "MSG of pheromones," "instant piece of mind," and "crush pheromone." But Alpha Dream himself refused to stock it on safety grounds. The current supply has even more reason for caution, given its higher estrogenic potential.